Tissue Research
TB-500 — Research Peptide
Thymosin Beta-4 fragment studied for its role in cell migration via G-actin sequestration and actin polymerization in preclinical models.
$74.99 · 10mg
Third-party tested · Freedom Diagnostics
View COA · Third-party COA · Lot EP-2030K
- Ships from within the U.S.
- Pay by card, Apple Pay, Venmo, Cash App or crypto
- Stored frozen at −10 °F until ship day
- Batch ID and QR code on the label
For in-vitro laboratory research use only. Not for human consumption.
Specifications
TB-500 at a glance.
- Size
- 10mg
- Form
- Lyophilized powder
- Storage
- −20°C
- Purity
- 99.30% (HPLC-UV · Freedom Diagnostics COA)
- Molecular weight
- 4,963.44 g/mol
- Molecular formula
- C₂₁₂H₃₅₀N₅₆O₇₈S
- Certificate of Analysis
- Third-party tested (Lot EP-2030K · Freedom Diagnostics)
- Category
- Tissue Research
Third-party COA · Lot EP-2030K
Documented by a third-party lab.
Issued by Freedom Diagnostics Testing, an independent lab, with Excalibur Peptides as the client. It covers lot EP-2030K. The PDF here is the same report the lab hosts.
Independent verification
Verify on Freedom Diagnostics.
This TB-500 Certificate of Analysis is hosted on Freedom Diagnostics Testing's own site. Search the code below on the lab's lookup page, or open the lab-hosted PDF. Values are shown as printed on the certificate.
Search code: Exca2610050658
- Lab
- Freedom Diagnostics Testing
- Lot
- EP-2030K
- Sample
- TB-500 10mg
- Received
- 10/5/2026
- Reported
- 10/6/2026
- Purity (HPLC-UV)
- 99.30%
- Identity (LC-MS)
- Confirmed
- Net content
- 9.77 mg
View lab-hosted COA (PDF on coas.freedomdiagnosticstesting.com)
Previous reports
Previous batch — not the batch currently shipping
Third-party reports for earlier batches of TB-500, kept for transparency. Values as printed on each report.
- Received
- 06/09/2026
- Lab
- Freedom Diagnostics Testing
- Lot (cap colour)
- Clear Cap/Black Crimp
- HPLC purity
- 99.33%
What's in the box
One vial, part by part.
10mg of TB-500, supplied as a lyophilized powder in a sealed glass vial.
On the label
Clearly labeled.
Printed label
Product name, size and a research-use-only statement.
Batch ID
A batch number is printed on every label.
QR code
Printed on the label, next to the batch ID.
Research-use line
“For research and laboratory use only — not for human consumption” runs along the bottom of the label.
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Research
Research background.
Chemical identity, proposed mechanism and published preclinical literature, for laboratory reference.
Mechanism of action
TB-500 is a synthetic peptide related to Thymosin Beta-4 (Tβ4), a naturally occurring 43-amino-acid peptide that is the principal G-actin-sequestering molecule in many cell types. Published research on Tβ4 and its fragments has examined actin monomer binding, actin polymerization dynamics and cell-migration behavior in cultured cells.
Research observations
- G-actin monomer sequestration characterized in published biochemical studies of Tβ4
- Actin polymerization dynamics examined in cell-free and cultured-cell systems
- Cell-migration behavior examined in published in-vitro assays
- Integrin-linked kinase signaling examined in published mouse cardiac cell models
- Structure–activity work on the actin-binding region of Tβ4 reported in the literature
Key research & publications
- Safer et al. (1991) — Identified Thymosin Beta-4 as the major G-actin-sequestering peptide in cells.
- Bock-Marquette et al. (2004) — Examined Tβ4 signaling through integrin-linked kinase in mouse cardiac cell models.
- Kleinman & Sosne (2016) — Review of published Thymosin Beta-4 research in corneal cell and tissue models.
Further reading
Explore our in-depth guide to TB-500 (Thymosin Beta-4) research, including mechanisms of action and preclinical findings.
Frequently asked questions.
What is TB-500?
TB-500 is a synthetic peptide related to Thymosin Beta-4 (Tβ4), the 43-amino-acid peptide that is the principal G-actin-sequestering molecule in many cell types. Published research on Tβ4 has examined actin monomer binding, actin polymerization and cell migration in cultured cells. Excalibur Peptides supplies it as a lyophilized research chemical for laboratory use only.
Where can I buy TB-500 for research?
Excalibur Peptides sells TB-500 on this page as a 10mg vial of lyophilized powder, for in-vitro laboratory research only. Orders ship from Austin, Texas, to addresses within the United States, and the product's third-party Certificate of Analysis is published in our COA database. Buyers must be 21 or older and confirm research-use-only status at checkout.
How is TB-500 tested, and where is its COA?
TB-500 is third-party tested by Freedom Diagnostics Testing: purity by HPLC and identity by LC-MS. The Certificate of Analysis is published in our COA database, and the report can be looked up on the lab's own site with search code Exca2610050658.
How should TB-500 be stored in the lab?
Keep lyophilized TB-500 sealed at −20 °C, protected from light and moisture, as listed on this page. Let the vial reach room temperature before opening so moisture does not condense on the powder, and avoid repeated freeze–thaw cycles.
How fast does TB-500 ship?
TB-500 ships from Austin, Texas. Orders placed before 2 PM EST on a business day ship the same day, and delivery within the United States typically takes 2–4 business days. A tracking number is emailed when the order ships.
What payment methods can I use to buy TB-500?
We accept credit and debit cards, Apple Pay, Venmo, Cash App and cryptocurrency. Prices are in U.S. dollars.
Is TB-500 approved by the FDA?
No. The TB-500 supplied by Excalibur Peptides is not approved by the FDA for human or veterinary use. It is sold only for in-vitro laboratory research and identification purposes and is not for human consumption.
For research and laboratory use only. Not for human consumption.
All products sold on this website are intended for in-vitro laboratory research and identification purposes only. They are not for human or veterinary use and are not for human consumption.
All information is provided for educational and research purposes. Excalibur Peptides does not condone or promote the use of any product for any purpose other than legitimate scientific research and compound identification.