Cellular Research · New
MT-2 (Melanotan II) — Research Peptide
Melanotan II, a cyclic α-MSH analog and non-selective melanocortin receptor agonist (MC1R, MC3R, MC4R, MC5R) studied in melanocortin receptor binding and signaling research.
$44.99 · 10mg
Third-party tested · Freedom Diagnostics
View lab-hosted COA · Third-party COA · Lot EP-51184K
- Ships from within the U.S.
- Pay by card, Apple Pay, Venmo, Cash App or crypto
- Stored frozen at −10 °F until ship day
- Batch ID and QR code on the label
For in-vitro laboratory research use only. Not for human consumption.
Specifications
MT-2 (Melanotan II) at a glance.
- Size
- 10mg
- Form
- Lyophilized powder
- Storage
- −20°C (Protected from light and moisture)
- Purity
- 99.87% (HPLC-UV · Freedom Diagnostics COA)
- Molecular weight
- 1024.18 g/mol
- Molecular formula
- C₅₀H₆₉N₁₅O₉
- Certificate of Analysis
- Third-party tested (Lot EP-51184K · Freedom Diagnostics)
- Category
- Cellular Research
- Sequence
- Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂
Third-party COA · Lot EP-51184K
Documented by a third-party lab.
Issued and hosted by Freedom Diagnostics Testing, the independent lab that ran it, with Excalibur Peptides as the client. It covers lot EP-51184K. Open the lab-hosted report, or look it up with the search code.
Independent verification
Verify on Freedom Diagnostics.
This MT-2 (Melanotan II) Certificate of Analysis is hosted on Freedom Diagnostics Testing's own site. Search the code below on the lab's lookup page, or open the lab-hosted PDF. Values are shown as printed on the certificate.
Search code: Exca2609280347
- Lab
- Freedom Diagnostics Testing
- Lot
- EP-51184K
- Sample
- Melanotan-II 10mg
- Received
- 9/28/2026
- Reported
- 9/29/2026
- Purity (HPLC-UV)
- 99.87%
- Identity (LC-MS)
- Confirmed
- Net content
- 10.01 mg
View lab-hosted COA (PDF on coas.freedomdiagnosticstesting.com)
What's in the box
One vial, part by part.
10mg of MT-2 (Melanotan II), supplied as a lyophilized powder in a sealed glass vial.
On the label
Clearly labeled.
Printed label
Product name, size and a research-use-only statement.
Batch ID
A batch number is printed on every label.
QR code
Printed on the label, next to the batch ID.
Research-use line
“For research and laboratory use only — not for human consumption” runs along the bottom of the label.
More in Cellular Research.
Research
Research background.
Chemical identity, proposed mechanism and published preclinical literature, for laboratory reference.
Mechanism of action
Melanotan II (MT-2) is a synthetic cyclic heptapeptide analog of alpha-melanocyte-stimulating hormone (α-MSH). A lactam bridge between its Asp and Lys residues constrains the core His-D-Phe-Arg-Trp sequence, giving it markedly higher potency than linear α-MSH in melanotropic bioassays. It acts as a non-selective agonist at melanocortin receptors MC1R, MC3R, MC4R and MC5R, and has been used in published preclinical research as a pharmacological tool for studying MC1R signaling in melanocytes and central MC3R/MC4R signaling in rodent models.
Research observations
- Non-selective agonism at MC1R, MC3R, MC4R and MC5R characterized in receptor studies
- MC1R-mediated cAMP signaling examined in cultured melanocyte models
- Central MC4R signaling examined in published rodent research
- Lactam-bridged cyclic structure confers resistance to proteolysis compared with linear α-MSH
- Potency of cyclic lactam α-MSH analogs studied in melanotropic bioassays
Key research & publications
- Al-Obeidi et al. (1989) — Described the design of cyclic lactam α-MSH analogs with high potency in melanotropic bioassays, the series that produced Melanotan II.
- Fan et al. (1997) — Used MT-II and the melanocortin antagonist SHU9119 as pharmacological tools to examine central MC4R signaling in mouse models.
- Hadley & Dorr (2006) — Review of historical milestones in melanocortin peptide research, including the development of Melanotan II and related analogs.
Frequently asked questions.
What is MT-2 (Melanotan II)?
MT-2 (Melanotan II) is a synthetic cyclic heptapeptide analog of alpha-melanocyte-stimulating hormone, Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂ (C₅₀H₆₉N₁₅O₉). It is a non-selective agonist at the melanocortin receptors MC1R, MC3R, MC4R and MC5R and is used as a pharmacological tool in receptor signaling research.
Where can I buy MT-2 (Melanotan II) for research?
Excalibur Peptides sells MT-2 (Melanotan II) on this page as a 10mg vial of lyophilized powder, for in-vitro laboratory research only. Orders ship from Austin, Texas, to addresses within the United States, and the product's third-party Certificate of Analysis is published in our COA database. Buyers must be 21 or older and confirm research-use-only status at checkout.
How is MT-2 (Melanotan II) tested, and where is its COA?
MT-2 (Melanotan II) is third-party tested by Freedom Diagnostics Testing: purity by HPLC and identity by LC-MS. The Certificate of Analysis is published in our COA database, and the report can be looked up on the lab's own site with search code Exca2609280347.
How should MT-2 (Melanotan II) be stored in the lab?
Keep lyophilized MT-2 (Melanotan II) sealed at −20 °C, protected from light and moisture, as listed on this page. Let the vial reach room temperature before opening so moisture does not condense on the powder, and avoid repeated freeze–thaw cycles.
How fast does MT-2 (Melanotan II) ship?
MT-2 (Melanotan II) ships from Austin, Texas. Orders placed before 2 PM EST on a business day ship the same day, and delivery within the United States typically takes 2–4 business days. A tracking number is emailed when the order ships.
What payment methods can I use to buy MT-2 (Melanotan II)?
We accept credit and debit cards, Apple Pay, Venmo, Cash App and cryptocurrency. Prices are in U.S. dollars.
Is MT-2 (Melanotan II) approved by the FDA?
No. The MT-2 (Melanotan II) supplied by Excalibur Peptides is not approved by the FDA for human or veterinary use. It is sold only for in-vitro laboratory research and identification purposes and is not for human consumption.
For research and laboratory use only. Not for human consumption.
All products sold on this website are intended for in-vitro laboratory research and identification purposes only. They are not for human or veterinary use and are not for human consumption.
All information is provided for educational and research purposes. Excalibur Peptides does not condone or promote the use of any product for any purpose other than legitimate scientific research and compound identification.